UNCOVERING PERTURBATIONS IN HUMAN HEMATOPOIESIS ASSOCIATED WITH HEALTHY AGING AND MYELOID MALIGNANCIES AT SINGLE-CELL RESOLUTION

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages.Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs.In this study, we used single-cell RNA sequencing (scRNA-seq) to characterize an enri

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Truth in an Evolutionary Perspective

The perspective drawn from evolutionary science, undoubtedly one of the most remarkable intellectual achievements in our conception of the world, poses a deep challenge to epistemology and the meaning of truth.The read more present paper aims to examine the difficulties offered by the prevailing biological model for the emergence and development of

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Incidence of household catastrophic and impoverishing health expenditures among patients with Breast Cancer in Iran

Abstract Background Breast cancer disease is the most common cancer among Iranian women and imposing a significant financial burden on the households.This study calculated out-of-pocket (OOP), catastrophic health expenditure (CHE), and impoverishing health spending attributed to breast cancer in Iran.Methods In this cross-sectional household study,

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